A Simple Solution to Chromatography for High-Purity Protein Preparations: The Modular Approach

With the completion of the human genome project and the subsequent sequencing of the genomes of most model organisms, a wealth of transcriptional data has emerged to broaden our understanding of cellular mechanisms. Technologies including DNA microarrays, real-time PCR, ultra-high throughput DNA sequencing, and intergenic chip-on-chip arrays have allowed researchers to hone in on specific genes implicated in a number of diseases and signaling events. In the post-genomic phase, the focus is shifting toward proteomics studies and the characterization of the proteins encoded by the identified genes. Chromatographic purification is an important tool in proteomic studies and it is the first step of any functional characterization of proteins.

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