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Sean and Frank: Kings of the MIQE

 :: Posted by American Biotechnologist on 03-01-2012

Since time immemorial, (or at least stretching back 2 to 3 years…), the American Biotechnologist has been a staunch advocate of the MIQE standards for real-time qPCR and has presented videos, technotes and papers from Bio-Rad qPCR experts. Dr. Sean Taylor’s video “Applications of MIQE to Real Time Quantitative PCR” has become and instant internet sensation and Dr. Francisco Bizouarn’s slideshow on “Fast qPCR assay optimization and validation techniques for HTS” is enshrined in the SlideShare museum hall of fame (at least on our site). Now, these two world class scientists have finally gotten the recognition they deserve.

This week, Sean and Frank were interviewed by the PCR Insider regarding the importance of following MIQE when conducting qPCR studies and Bio-Rad’s role in the dissemination of these crucial guidelines.

Check out the story on the PCR Insider (subscription required), and long live the Kings Sean and Frank!

Efficient Electrophoresis and Protein Blotting: Aiding Advances in Cardiomyopathy Research

 :: Posted by American Biotechnologist on 11-17-2011

A native of Trinidad and Tobago, Dr Aldrin Gomes decided to specialize in the biochemical differences between normal and diseased hearts in his graduate studies at the University of the West Indies. A significant portion of his research utilized protein separation and purification techniques, making SDS-PAGE electrophoresis and protein blotting an essential tool in most of his experiments. But in a country where resources are scarce, unrelenting heat is destructive to sensitive biological materials, and slow delivery times are common for product orders, Gomes and his colleagues began to analyze the electrophoretic workflow to determine how to make the process as efficient as possible. “Because we performed a lot of electrophoresis, we published some articles whereby we looked at how we could standardize things to improve resolution in our results,” says Gomes. “We heavily researched aliquoting methods, sample buffers (methods for making them and determining actual shelf lives), whether or not buffers can be reused — even minor factors such as gel pouring techniques and plate thickness.”

Since Gomes “grew up,” scientifically speaking, in an environment where experiments must be planned far in advance and resources cannot be wasted, he cultivated the habit of designing experiments and procedures that made the best possible use of tools and time while ensuring optimal results. This followed him through his graduate work and his subsequent career, first as a research associate, then in his current role as assistant professor in the Neurobiology, Physiology and Behavior department in the College of Biological Sciences, and Physiology and Membrane Biology department in the School of Medicine at UC Davis.

Read more…

Genomes, Phenomes and Personalized Medicine

 :: Posted by American Biotechnologist on 10-26-2011

George Church, who it may be argued is the father of personalized genomics, spoke at TEDMED about the future of personal genomics and what research has yielded so far. Ironically, when he gave this talk one year ago in October of 2010, a google search of the term “synthetic personal genomes” did not yield any results (according to Dr. Church). The same search done today returns over 900,000 results! Obviously George continues to be light years ahead of the crowd. Have a look at the video below and see for yourself.

A Scientific Legend’s Approach to Solving Problems and Developing Technologies

 :: Posted by American Biotechnologist on 07-26-2011

George Church is one of the founders of the human genome project and continues to play an important role in the personal genome project, stem cell research and biofuel research. In this video, Dr. Sriram Kosuri, a Postdoctoral fellow in George’s lab at Harvard University discusses the Church lab’s approach to solving problems and developing technologies.

George Church: The father of personalized genomics

 :: Posted by American Biotechnologist on 06-09-2011

Dr. George Church is a professor of genetics at Harvard and a professor of Health Sciences & Technology at Harvard and MIT. George helped initiate the human genome project in 1994 and has played a pivotal role in molecular genetics ever since. In 2005, Dr. Church initiated the Personal Genome Project which aims to make personal genome sequencing more affordable, accessible, and useful for humankind.

The following educational and entertaining video first aired in July 2009 and has been viewed on YouTube by over 15,000 people. After watching this video, how much closer do you thing George is to accomplishing his goal and how much has changed since this video first aired almost two years ago?