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:: Posted by American Biotechnologist on 02-02-2012
Traditional RNA isolations kits and techniques usually isolate linear RNA transcripts while discarding circular material that are thought to be unimportant. However, a new study at the Stanford School of Medicine suggests that circular RNA may play a more important role in gene expression than previously thought.
In the classical model of gene expression, the genetic script encoded in our genomes is expressed in each cell in the form of RNA molecules, each consisting of a linear string of chemical “bases”. It may be time to revise this traditional understanding of human gene expression, as new research suggests that circular RNA molecules, rather than the classical linear molecules, are a widespread feature of the gene expression program in every human cell. The results are published in the Feb. 1 issue of the online journal PLoS ONE.
:: Posted by American Biotechnologist on 01-09-2012
When I first read this I thought that it was simply written by a mistaken undergrad student. Alas, it is not!
In the chemistry of the living world, a pair of nucleic acids—DNA and RNA—reign supreme. As carrier molecules of the genetic code, they provide all organisms with a mechanism for faithfully reproducing themselves as well as generating the myriad proteins vital to living systems.
Yet according to John Chaput, a researcher at the Center for Evolutionary Medicine and Informatics, at Arizona State University’s Biodesign Institute®, it may not always have been so.
:: Posted by American Biotechnologist on 12-13-2011
Nate “the great” Krefman of Bad Habits and Stickleback fame has once again outdone himself with a stellar lab video performance. Now, I have to admit that what you are about to see is some of the silliest and dorkiest filmography that I have ever watched but it is always a blast watching a highly educated molecular biologist have fun in the lab.
My challenge to you, my dear readers, is to send me the dorkiest and silliest lab videos you have seen on the web (or performed yourself…anonymity will be honored where requested). Once all submissions are in we will hold a vote to see who can be named the dorkiest molecular biologist of the year!
Submissions can be sent either by commenting on this post or by emailing avi (at) americanbiotechnolgist (dot) com.
:: Posted by American Biotechnologist on 11-16-2011
Human pluripotent stem cells, which can develop into any cell type in the body, rely heavily on glycolysis, or sugar fermentation, to drive their metabolic activities.
In contrast, mature cells in children and adults depend more on cell mitochondria to convert sugar and oxygen into carbon dioxide and water during a high energy-producing process called oxidative phosphorylation for their metabolic needs.
How cells progress from one form of energy production to another during development is unknown, although a finding by UCLA stem cell researchers provides new insight for this transition that may have implications for using these cells for therapies in the clinic. Read the rest of this entry »