Posts Tagged ‘genomics’

New Molecular Tool for Prognosis and Treatment of Brain Tumors

 :: Posted by American Biotechnologist on 01-17-2012

In a paper recently published in BMC Medical Genomics, scientists from Sandra L Rodriguez-Zas’ lab at the University of Illinois have identified a cohort of biomarkers that help predict survivability of patients who are afflicted with the aggressive malignant Glioblastoma multiforme brain tumor. The study also found that survivability varies between different genetic profiles and that factors such as race, gender and therapy may have a significant impact upon the survival and quality of life of individuals afflicted by glioblastoma multiforme.
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Genomic headphones and the $25,000 prize

 :: Posted by American Biotechnologist on 01-05-2012

Have you ever thought about what genomic DNA and MP3 headphones have in common? Dr. Erez Leiberman Aiden has and it has netted him a prestigious $25,000 prize and a 5 year, $2.5M new investigator award. What does one thing have to do with the other? Read on to find out! Read the rest of this entry »

Imagine where genomic technology can take us

 :: Posted by American Biotechnologist on 01-04-2012

Inspiring words from NIH director Francis Collins.

3-D Mapping of the Human Genome

 :: Posted by American Biotechnologist on 01-04-2012

In the beginning, scientists sequenced the human genome. And the human genome was good…but not good enough.

Next came epigenetics. And epigenetics was also good. But not good enough.

And then scientists thought very hard and invented a technology for producing three-dimensional genome structures. And three-dimensional structures was good. Very good.

In a Nature Biotechnology article published December 25th, 2011, a team of scientists from the University of Southern California, described a method for genome-wide mapping of chromatin interactions known as tethered conformation capture (TCC). The method performs ligations on solid substrates rather than in solution, which helps facilitate a detailed analysis of interactions within and between chromosomes. The team then developed a computational method to translate the TCC data into physical chromatin contacts in a population of three-dimensional genome structures.

Understanding the structure of the genome is crucial to understanding its function as a whole, said Lin Chen, professor of molecular biology at the USC Dornsife College of Letters, Arts and Sciences.

“Everything biological works in the three dimensions,” Chen said. “Therefore, to understand it completely, you have to understand it three-dimensionally.”

By analyzing the differences and similarities in genome structure between various cells, scientists are able to discern what basic principles of 3-D organization are. In addition, the structure allows scientists to see where each gene is located relative to any other gene and how this arrangement is important to cellular functions.

Thanks to USC for contributing to this story.

Feeling short changed? You may need more genes!

 :: Posted by American Biotechnologist on 11-23-2011

New research sifts through the entire genome of thousands of human subjects to look for genetic variation associated with height. The results of the study, published by Cell Press in the December issue of the American Journal of Human Genetics, suggest that uncommon genetic deletions are associated with short stature.

Height is a highly heritable trait that is associated with variation in many different genes. “Despite tremendous recent progress in finding common genetic variants associated with height, thus far these variants only explain about 10% of the variation in adult height,” explains senior study author, Dr. Joel N Hirschhorn, from Children’s Hospital Boston and the Broad Institute. “It has been estimated that about half of height variation could eventually be accounted for by the sorts of variants we’ve been looking at, so it is possible that other types of genetic variants, such as copy number variants (CNVs), may also contribute to the genetic variation in stature.”
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