Posts Tagged ‘cell biology’

Regulating Cellular Trafficking

 :: Posted by American Biotechnologist on 09-23-2013

Molecular microbiologists at the University of Southern California (USC) have uncovered intricate regulatory mechanisms within the cell that could lead to novel therapeutics for the treatment of cancer and other diseases. Their findings, which have long-standing significance in the basic understanding of cell biology, appear in the journal Nature Cell Biology.

“Our research reveals a new regulatory mechanism that coordinates two distinct intracellular processes that are critical to cellular homeostasis and disease development,” said Chengyu Liang, M.D., Ph.D., a member of the USC Norris Comprehensive Cancer Center and principal investigator of the study.

The endoplasmic reticulum (ER) and Golgi apparatus are cellular organelles in eurkaryotic organisms where proteins are synthesized and packaged for secretion through the body. The trafficking of proteins between the ER and Golgi must be tightly modulated to maintain the health of the cell and prevent diseases like cancer from taking hold.

“Interest in the role of ER-Golgi network during cancer cell death has been gaining momentum,” said Shanshan He, Ph.D., research associate at the Keck School of Medicine of USC and one of the study’s first authors. “In this study, we identified a novel regulatory factor for the Golgi-ER retrograde transport and a new mechanistic connection between the physiological trafficking and the autophagic transportation of cellular material.”

The researchers discovered that the UV irradiation resistance-associated gene protein (UVRAG), which has been implicated in the suppression of colon and breast cancer, coordinates trafficking of proteins between the ER and Golgi apparatus and also autophagy, the natural process of breaking down cellular components.

“Given that the ER-Golgi network is often dismantled in malignant conditions and that UVRAG is intensively involved in different types of human cancers, this study gives us a new avenue to investigate anti-cancer agents that target UVRAG and/or the ER-Golgi pathway in cancer and other relevant diseases,” Liang said.

Source: University of Southern California – Health Sciences. “Protein identified that regulates cellular trafficking, potential for anti-cancer therapy.” ScienceDaily, 22 Sep. 2013. Web. 24 Sep. 2013.

New method of endocrine signaling discovered

 :: Posted by American Biotechnologist on 02-06-2013

Cells communicate in many ways. The can communicate through direct contact (juxtacrine signaling), over short distances (paracrine signaling), or over large distances (endocrine signaling). Until now, endocrine signaling research has focused primarily on hormones which can transverse relatively large distances in order to convey their message to target cells. Now, scientists at UCLA have discovered a previously unknown method of long distance cell-to-cell communication that does not involve the use of hormones.

In a study published in the American Journal of Translational Research, Dr. Keith Norris, senior author of the research and assistant dean for clinical and translational science at the David Geffen School of Medicine at UCLA, and his team found that cells located on the inside of a hormonally impervious membrane were able to receive messages regulating their calcium signaling pathways from cells located outside the membrane.

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Is Deformation the New Transformation?

 :: Posted by American Biotechnologist on 01-23-2013

Researchers from MIT have now found a safe and efficient way to get large molecules through the cell membrane, by squeezing the cells through a narrow constriction that opens up tiny, temporary holes in the membrane. Any large molecules floating outside the cell — such as RNA, proteins or nanoparticles — can slide through the membrane during this disruption.

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3D Biology Game: An Idea Worth Funding

 :: Posted by American Biotechnologist on 12-06-2012

This past summer a group of artists and indie game developers in the Seattle area attempted to develop a super-cool video game that allowed player to explore the inside of a cell as if they were actually inside the 3D structure. Unfortunately, the team was unsuccessful in meeting its funding goal, however, they left a strong impresson on me and I believe that they have a product which can seriously help revitalize the biology classroom.

Checkut the video from Kinect Biology and give us your feedback. Do you think that there idea is worth funding?

Precision Motion Tracking – Thousands of Cells at a Time

 :: Posted by American Biotechnologist on 09-18-2012

Researchers have developed a new way to observe and track large numbers of rapidly moving objects under a microscope, capturing precise motion paths in three dimensions.

Over the course of the study–reported online Sept. 17, 2012, in the Proceedings of the National Academy of Sciences–researchers followed an unprecedented 24,000 rapidly moving cells over wide fields of view and through large sample volumes, recording each cell’s path for as long as 20 seconds.

“We can very precisely track the motion of small things, more than a thousand of them at the same time, in parallel,” says research lead and National Science Foundation CAREER awardee Aydogan Ozcan. an electrical engineering and bioengineering professor at UCLA. “We were able to achieve sub-micron accuracy over a large volume, allowing us to understand, statistically, how thousands of objects move in different ways.”

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