Now that we’ve finished our series on Proteomics Application Tips, it’s time to reward ourselves with a captivating talk by Professor Danny Hillis on Understanding Cancer Through Proteomics. Yes…he’s preaching to the choir, but it’s still fun to see our cause promoted on the “big screen.” Enjoy!
Posts Tagged ‘cancer research’
“This is not some horrible sci-fi movie come true but, instead, normal cells carrying out their daily duties,” said Florida State University cell biologist Tom Roberts. For 35 years he has studied the mechanical and molecular means by which amorphous single cells purposefully propel themselves throughout the body in amoeboid-like fashion ––absent muscles, bones or brains.
Over the next decade, the population of cancer survivors over 65 years of age will increase by approximately 42 percent.
“We can expect a dramatic increase in the number of older adults who are diagnosed with or carry a history of cancer,” said Julia Rowland, Ph.D., director of the Office of Cancer Survivorship in the Division of Cancer Control and Population Sciences at the National Cancer Institute (NCI). “Cancer is largely a disease of aging, so we’re seeing yet another effect of the baby boom generation and we need to prepare for this increase.”
Researchers have discovered a method for simultaneously visualizing gene number and protein expression in individual cells. The fluorescence microscopy technique could permit a detailed analysis of the relationship between gene status and expression of the corresponding protein in cells and tissues, and bring a clearer understanding of cancer and other complex diseases, according to researchers who led the study.
The new technique is called the fluorescent in situ gene protein assay. It combines traditional fluorescent in situ hybridization (FISH) with the in situ proximity ligation assay, which is capable of resolving individual protein molecules.
Dr John J Rossi’s titles and accolades are many and varied — and well earned. In his current affiliation with the City of Hope Comprehensive Cancer Center, Rossi serves as chair and professor of molecular and cellular biology, dean of the graduate school of biological sciences, and associate director for laboratory research. He is co-leader of the cancer biology program and the first holder of the Lidow Family Research Chair. These professional accomplishments are complemented by numerous awards, including a 2002 Merit Award in the Division of AIDS, National Institute of Allergy and Infectious Diseases. The common thread that weaves all of these activities and achievements together continues to be an unabashed enthusiasm for and curiosity toward scientific discovery — specifically in the molecular genetics of disease.
Rossi received his doctoral degree in microbial genetics in the late 1970s. At the time, cloning was only just becoming a tool that researchers could use, and with Rossi’s exposure to this now basic technique, his fascination with genetics turned to the molecular aspects of the discipline. Rossi was drawn to postdoctoral studies in Dr Arthur Landy’s lab at Brown University because of Landy’s groundbreaking work in sequencing genetic information for the bacteriophage lambda. Landy’s work focused on trying to understand some of the sequences of the attachment site of the bacteriophage in its host chromosome. He also completed the first restriction map of any lambda phage. Rossi was particularly attracted by the technology he would have access to in this forward-thinking environment.