Posts Tagged ‘cancer research’

How cancer cells break free from tumors

 :: Posted by American Biotechnologist on 10-09-2012

Although tumor metastasis causes about 90 percent of cancer deaths, the exact mechanism that allows cancer cells to spread from one part of the body to another is not well understood. One key question is how tumor cells detach from the structural elements that normally hold tissues in place, then reattach themselves in a new site.

A new study from MIT cancer researchers reveals some of the cellular adhesion molecules that are critical to this process. The findings, published Oct. 9 in Nature Communications, offer potential new cancer drug targets, says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science, and leader of the research team.

Read more…

Killing tumors by helping them survive!

 :: Posted by American Biotechnologist on 08-14-2012

To survive, tumors need blood supply to provide them with nutrients and oxygen. To get that supply, cancer cells stimulate new blood vessel growth—a process called tumor angiogenesis. Many attempts have been made to inhibit this process as a means to choke off tumors. But tumor angiogenesis can be sloppy, resulting in immature and malformed blood vessels. Since anti-cancer drugs are carried to tumors by the bloodstream, abnormal blood vessel development also hampers delivery. What if, rather than putting a stop to angiogenesis, we could help tumor blood vessels mature more completely, so tumor-killing therapies could more effectively reach their targets? This counterintuitive concept was proposed several years ago, but researchers lacked a way to do it. Now, in a paper published August 14 in the journal Cancer Cell, Sanford-Burnham researchers found a molecule that promotes the tumor vessel maturation process—a discovery that might provide a method for improving cancer drug delivery.

“Our finding suggests that an ability to regulate this molecule could allow us to solve various problems caused by blood vessel abnormalities, including inefficient drug delivery to tumors,” said Masanobu Komatsu, Ph.D., associate professor at Sanford-Burnham and senior author of the study.

Read more…

The FUNNIEST Science Video On The Web!

 :: Posted by American Biotechnologist on 04-19-2012

This is by far one of the funniest scientific-genre videos on the web. You simply must watch.

One of my favourite lines from the video is when he explains that hundreds of pounds of beard hair sample is kept at -80C “not for preservation…just because I don’t like the smell!” What’s your favourite part?

New Molecular Tool for Prognosis and Treatment of Brain Tumors

 :: Posted by American Biotechnologist on 01-17-2012

In a paper recently published in BMC Medical Genomics, scientists from Sandra L Rodriguez-Zas’ lab at the University of Illinois have identified a cohort of biomarkers that help predict survivability of patients who are afflicted with the aggressive malignant Glioblastoma multiforme brain tumor. The study also found that survivability varies between different genetic profiles and that factors such as race, gender and therapy may have a significant impact upon the survival and quality of life of individuals afflicted by glioblastoma multiforme.
Read the rest of this entry »

Proteomics: The Next Frontier in Cancer Research

 :: Posted by American Biotechnologist on 12-15-2011

Now that we’ve finished our series on Proteomics Application Tips, it’s time to reward ourselves with a captivating talk by Professor Danny Hillis on Understanding Cancer Through Proteomics. Yes…he’s preaching to the choir, but it’s still fun to see our cause promoted on the “big screen.” Enjoy!