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A blasting good way to understand the complex and beautiful world of cell biology

 :: Posted by American Biotechnologist on 02-06-2012

The winner of the 2011 National Science Foundation’s International Science and Engineering Visualization Challenge have been announced and not surprisingly, one of our favorite contenders, FoldIt! has taken top prize. Since we have written about FoldIt! in the past (see Guilt-Free Computer Gaming for Protein Scientists) we won’t belabor the point any more. However, we will bring to your attention one of the runners up, Meta!Blast which is a serious game that explores the complexities of cellular and metabolic biology.

According to the website, Meta!blast, developed at Iowa State University, is a real-time 3D action-adventure video game, aimed at high school and undergraduate student audiences, meant to provide an entertaining, engaging experience while simultaneously educating players about cell biology. Players discover that their entire lab has been sucked up by a plant cell and it is their job to rescue the group while dodging the hazards associated with the internal cell environment. By immersing players into a virtual cell environment and allowing them to interact with it on their own terms, the developers hope that players will come to a greater understanding of the cell than they could learn from traditional diagrams and textbooks.

The game is available in both windows and mac version and can be downloaded at http://www.metablast.org/downloads

How bureaucracy is killing innovative medical research

 :: Posted by American Biotechnologist on 12-12-2011

The promise of stem cell research for drug discovery and cell-based therapies depends on the ability of scientists to acquire stem cell lines for their research.

A survey of more than 200 human embryonic stem cell researchers in the United States found that nearly four in ten researchers have faced excessive delay in acquiring a human embryonic stem cell line and that more than one-quarter were unable to acquire a line they wanted to study.

“The survey results provide empirical data to support previously anecdotal concerns that delays in acquiring or an inability to acquire certain human embryonic stem cell lines may be hindering stem cell science in the United States,” said Aaron Levine, an assistant professor in the School of Public Policy in the Ivan Allen College of Liberal Arts at the Georgia Institute of Technology.

Results of the survey were published in the December issue of the journal Nature Biotechnology. Funding for the study was provided by the Kauffman Foundation’s Roadmap for an Entrepreneurial Economy Program.
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A genetic breakthrough for cleft lip

 :: Posted by American Biotechnologist on 11-29-2011

Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way to prevent or treat the conditions in humans.

Cleft lip and cleft palate are among the most common birth defects, with treatment requiring multiple cycles of surgery, speech therapy and orthodontics. To date, there have been very few pre-clinical methods that allow researchers to study the molecular causes of these malformations. In particular, there has been a lack of animal models that accurately reflect the contribution of multiple genes to these congenital deformities in humans.
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$1.1 Billion investment coming to Connecticut genomic research community

 :: Posted by American Biotechnologist on 10-27-2011

According to theday.com, a package that promises huge economic development and jobs growth in the state of Connecticut, passed both chambers of the General Assembly Wednesday night with nearly unanimous bipartisan support.

As reported last month, Connecticut Gov. Dannel Malloy and state economic development leaders had invited The Jackson Laboratory (JAX) to launch a new center for personalized medicine and systems genomics in Connecticut.
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Why depressed animals are a reason to celebrate

 :: Posted by American Biotechnologist on 10-25-2011

Washington State University researchers have taken a promising step toward creating an animal model for decoding the specific brain circuits involved in depression. By electrically stimulating a brain region central to an animal’s primary emotions, graduate student Jason Wright and his advisor Jaak Panksepp saw rats exhibit a variety of behaviors associated with a depressed, negative mood, or affect.

“We might now have a model that allows us to actually know where to look in the brain for changes relevant to depression, and we can monitor how activity in these regions change during states of negative affect and the restoration of positive affect,” says Wright. “There are no other models out there like this.”

The researchers caution that their work comes with a variety of caveats and that there are still many factors that need to be evaluated.

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